The effect of melatonin supplementation on lipid profile, oxidative stress, inflammatory marker, and sleep quality in patients with chronic kidney disease: a GRADE assessed meta-analysis

Key Points

• Melatonin supplementation can raise HDL-C levels, decrease oxidative stress, and improve sleep quality in chronic kidney disease patients.
• Specifically, the supplementation enhances HDL-C levels while simultaneously reducing markers of oxidative stress, which is beneficial.
• The assessment utilized a meta-analysis approach, consolidating multiple studies to determine the overall effect of melatonin on lipid profiles and sleep quality.
• Further clinical trials are needed to confirm these findings and explore the potential long-term benefits of melatonin supplementation.