Optimizing Enoxaparin Dosing in Asian Patients: The Critical Role of Age and Renal Function in Achieving Target Anti-Xa Levels

Figures

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  Figure 1. Distribution of weight-adjusted dosage (A) and steady-state peak anti-Xa levels (B) of enoxaparin. The outer curves (density plots) represent the density estimate of the data distribution, with wider sections indicating higher data density (more observations). The inner box plot includes a median line marking the median value of the dataset, a box spanning from the first quartile to the third quartile, and whiskers extending from the box representing 95% confidence interval. (A) The red horizontal line represents the drug manufacturer’s recommended weight-based dose, while blue dots represent individual enoxaparin weight-based dose values. (B) The area between red horizontal lines represents the target anti-Xa level range, with red dots representing individual anti-Xa level values.

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  Figure 2. Weight-based dose and probability to achieve therapeutic anti-Xa levels group by age. (A) Overview. The weight-based dose is the independent variable, achieving the anti-Xa target is the dependent variable, and the vertical axis shows the estimated probability. Patients were grouped by age (<80 years, red; ≥80 years, blue) for modeling, with data dots visualized at the bottom layer. (B) Zoomed-in region marked in light blue in (A) is shown, with 90% and 95% probabilities represented by yellow dotted lines, and the corresponding weight-based doses are displayed on the vertical blue and red dotted lines.

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  Figure 3. Weight-based dose and probability to achieve therapeutic anti-Xa levels group by eGFR. (A) Overview. The weight-based dose is the independent variable, achieving the anti-Xa target is the dependent variable, and the vertical axis shows the estimated probability. Patients were grouped by eGFR (≥60 mL/min, red; <60 mL/min, blue) for modeling, with data dots visualized at the bottom layer. (B) Zoomed-in region marked in light blue in (A) is shown, with 90% and 95% probabilities represented by yellow dotted lines, and the corresponding weight-based doses are displayed on the vertical blue and red dotted lines.