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January 1, 2026Cancer CommunicationsOpen Access

Multiplexed CRISPR/Cas9 Editing of Tumor Suppressor Genes in the Mouse Endometrium Recapitulates High-Risk Endometrial Carcinoma

Maria Vidal-Sabanés Raúl Navaridas Núria Bonifaci Ada Gay-Rua Damià Ortega-Peinado Joaquim Egea Mario Encinas Mario Encinas Alicia Llorente Xavier Dolcet

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Key Points

High-risk endometrial carcinoma was induced using multiplexed crispr/cas9 editing.
Key tumor suppressor genes were effectively targeted in the mouse endometrium, leading to significant tumor development.
The approach employed targeted genetic editing to unveil pathways associated with cancer progression.
Findings support the feasibility of using genetic tools in modeling human cancer in animal models.

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Implication

Observational analysis demonstrates high-risk endometrial carcinoma in a mouse model, indicating potential genetic editing applications.

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Cite This Study

Vidal-Sabanés et al. (2026) studied this question.

synapsesocial.com/papers/69a767d0badf0bb9e87e27ab https://doi.org/10.34133/cancomm.0010

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