Ononin combined with Lactobacillus paracasei alleviates DSS-induced ulcerative colitis by ferroptosis via inhibiting JAK2/STAT3 signaling pathway

Key Points

Colitis severity significantly decreases with the Ononin and Lactobacillus paracasei combination, showing enhanced gut health.
The study reports a protective mechanism primarily involving blockade of the JAK2/STAT3 signaling pathway.
Assessment using preclinical mouse models indicates a strong potential for new therapeutic strategies.
These findings highlight the importance of gut microbiota and iron regulation in managing ulcerative colitis.

Abstract

The combination of Ononin and Lactobacillus paracasei effectively ameliorated DSS-induced colitis in mice. Its protective mechanism involves suppressing inflammation and oxidative stress, inhibiting ferroptosis (potentially through blocking the JAK2/STAT3 pathway), and enhancing intestinal barrier integrity. These findings provide a strong preclinical rationale for developing this combination as a potential therapeutic strategy for UC.

Ononin combined with Lactobacillus paracasei alleviates DSS-induced ulcerative colitis by ferroptosis via inhibiting JAK2/STAT3 signaling pathway

Key Points

Abstract

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