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FGF19/FGFR4/KLB signaling participate in the ferroptosis regulation of hepatocellular carcinoma | Synapse
March 3, 2026
FGF19/FGFR4/KLB signaling participate in the ferroptosis regulation of hepatocellular carcinoma
JX
Jinkun Xia
MQ
Min Qiu
Kunming Institute of Botany
HM
Hucheng Ma
Nanjing Drum Tower Hospital
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Key Points
Ferroptosis regulation is crucial in hepatocellular carcinoma, influencing tumor survival.
Key findings reveal that FGF19 signaling significantly affects ferroptosis mechanisms in this cancer type.
Observational analysis identifies the interaction between FGFR4 and KLB in mediating cellular responses.
Targeting ferroptosis pathways may offer promising strategies for hepatocellular carcinoma treatment.
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Cite This Study
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Xia et al. (Sun,) studied this question.
synapsesocial.com/papers/69a76872badf0bb9e87e4af5
https://doi.org/https://doi.org/10.1016/j.ajg.2024.11.001