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March 3, 2026Medical Oncology

Significant reduction in CIPN grade over time, with fewer patients progressing to higher grades in the prophylactic versus non-prophylactic group, and significantly less need for gabapentin.

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Why the study?

Paclitaxel causes debilitating peripheral neuropathy that may limit chemotherapy, and the study aimed to evaluate vitamin B prophylaxis to reduce its severity, especially in diabetic patients, along with gabapentin needs and disease response.

Does vitamin B prophylaxis reduce the severity of paclitaxel-induced peripheral neuropathy in adult ovarian cancer patients?

Population

146 adult ovarian cancer patients receiving paclitaxel

Comparison

Vitamin B prophylaxis before paclitaxel vs vitamin B upon CIPN

Design

Randomized clinical trial

Follow-up

18 weeks

Authors

MHMahitab G. HaggagyFRFatma RaslanNSNorhan El Said

Discussion

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Member takes

Overview

Provides low-cost prophylaxis to enhance paclitaxel tolerance in ovarian cancer; confirms vitamin B efficacy in RCT and supports broader oncology research.

Key Points

  • Vitamin B prophylaxis may reduce the incidence of paclitaxel-induced neuropathy in diabetic ovarian cancer patients, improving their quality of life.
  • The trial observed a significant decrease in neuropathy symptoms in the vitamin B group compared to those not receiving this treatment.
  • Randomized clinical trial methodology was employed to analyze the efficacy of vitamin B and the impact of gabapentin involvement in treatment.
  • These findings support the integration of vitamin B supplementation in treatment protocols for diabetic ovarian cancer patients experiencing neuropathy.

Structured PICO

Does vitamin B prophylaxis reduce the severity of paclitaxel-induced peripheral neuropathy in adult ovarian cancer patients?

P
Population
146 adult ovarian cancer patients receiving paclitaxel for 18 weeks, including diabetic patients
I
Intervention
Vitamin B prophylaxis before starting paclitaxel
C
Comparator
Vitamin B given upon development of chemotherapy-induced peripheral neuropathy (CIPN)
O
Outcome
Severity of chemotherapy-induced peripheral neuropathy (CIPN grade over time)safety

Vitamin B prophylaxis significantly reduces paclitaxel-induced peripheral neuropathy severity and the need for gabapentin in ovarian cancer patients, minimizing dose reductions and improving progression-free survival.

Cite This Study

Haggagy et al. (2026) studied this question.

synapsesocial.com/papers/69a76896badf0bb9e87e5372https://doi.org/10.1007/s12032-026-03252-3
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