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March 4, 2026TrAC Trends in Analytical ChemistryOpen Access

Sigma-1 receptor as a Diagnostic and Imaging Biomarker: Advances in Translational Research

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Authors

PWPengcheng WangHarbin Institute of TechnologyYYY. YangChengdu University of TechnologyRHRui HuWuhan Institute of Physics and Mathematics

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Implication

This review examines sigma-1 receptor biology and its role as a diagnostic biomarker in neurodegenerative diseases, suggesting new therapeutic opportunities.

Key Points

  • The aim is to highlight the sigma-1 receptor's role in various diseases and its potential as a biomarker for diagnostics and imaging.
  • Reviewed sigma-1 receptor biology and its implications in Alzheimer’s and Parkinson’s diseases.
  • Evaluated current PET radioligands for noninvasive measurement of sigma-1 receptor availability.
  • Outlined design principles for sigma-1 receptor-targeted molecular probes.
  • Sigma-1 receptor acts as a key player in neurodegenerative and psychiatric disorders.
  • Current PET imaging techniques allow for effective patient stratification and evaluation of sigma-1 receptor-targeted therapies.
  • Recommendations for probe design can enhance translation and reliability in imaging studies.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69a7cc4cd48f933b5eed7e7fhttps://doi.org/10.1016/j.trac.2026.118777
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