What type of study is this?

This is a Literature Review study.

What question did this study set out to answer?

To explore the role of protein misfolding and ER stress in schizophrenia and the potential of sigma-1 receptor agonists as therapeutic agents.

November 11, 2025PsychopharmacologyOpen Access

Targeting endoplasmic reticulum stress and protein misfolding in schizophrenia: the emerging promise of sigma-1 receptor agonists

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Authors

MAMariam K Ahmed KAKareem Abdou WIWeam W. Ibrahim

Discussion

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Overview

Review highlights sigma-1 receptor agonists' potential to improve neuroprotection and restore proteostasis in schizophrenia, suggesting novel therapeutic strategies.

Key Points

To explore the role of protein misfolding and ER stress in schizophrenia and the potential of sigma-1 receptor agonists as therapeutic agents.
Review of literature on protein misfolding and ER stress in schizophrenia
Analysis of sigma-1 receptor function
Examination of neuroinflammatory pathways
Identified links between protein misfolding and schizophrenia pathology
Highlighted sigma-1 receptor's role in regulating ER stress and neuronal health
Discussed potential for sigma-1 receptor agonists to mitigate neuroinflammation and enhance neuroprotection

Cite This Study

Ahmed et al. (2025) studied this question.

synapsesocial.com/papers/69252ea3c0ce034ddc356800 https://doi.org/10.1007/s00213-025-06940-6

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November 11, 2025PsychopharmacologyOpen Access

Targeting endoplasmic reticulum stress and protein misfolding in schizophrenia: the emerging promise of sigma-1 receptor agonists

View Full Paper

Ask AI

Bookmark

Authors

MAMariam K Ahmed KAKareem Abdou WIWeam W. Ibrahim

Discussion

Member takes

Overview

Review highlights sigma-1 receptor agonists' potential to improve neuroprotection and restore proteostasis in schizophrenia, suggesting novel therapeutic strategies.

Key Points

To explore the role of protein misfolding and ER stress in schizophrenia and the potential of sigma-1 receptor agonists as therapeutic agents.
Review of literature on protein misfolding and ER stress in schizophrenia
Analysis of sigma-1 receptor function
Examination of neuroinflammatory pathways
Identified links between protein misfolding and schizophrenia pathology
Highlighted sigma-1 receptor's role in regulating ER stress and neuronal health
Discussed potential for sigma-1 receptor agonists to mitigate neuroinflammation and enhance neuroprotection

Cite This Study

Ahmed et al. (2025) studied this question.

synapsesocial.com/papers/69252ea3c0ce034ddc356800 https://doi.org/10.1007/s00213-025-06940-6

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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