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September 18, 2026CellsOpen Access

Intracellular Crosstalk Between NMDA and Sigma-1 Receptors: A Novel Mechanistic Insight Relevant to Neuropsychiatric Pharmacotherapy

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Authors

KLKatarzyna LipkeAPAgnieszka Piwowar

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Lipke et al. (2026) studied this question.

synapsesocial.com/papers/6aad0b3bde0393d728b89764https://doi.org/10.3390/cells15181689
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1TARGETING THE SIGMA-1/NMDA RECEPTOR COMPLEX TO AMELIORATE COGNITIVE DEFICITS AND NEGATIVE SYMPTOMS IN SCHIZOPHRENIA2026
  2. 2Targeting Neuroinflammation in Depression: The Integrative Role of Sigma‐1 Receptor Modulation2026 · 1 citations
  3. 3Sigma-1 receptor as a Diagnostic and Imaging Biomarker: Advances in Translational Research2026 · 1 citations
  4. 4Targeting Sigma-1 and Sigma-2 Receptors in Neuropathic Pain: Pharmacology, Ligand Development, and Translational Progress2026
  5. 5Targeting endoplasmic reticulum stress and protein misfolding in schizophrenia: the emerging promise of sigma-1 receptor agonists2025