Hypoxia-Triggered Dichloroacetate Delivery with Effective Reversal of Cancer Cell Reprogramming

rensong sun; Lei Wang; Ziang Liu; Hao Wu; Wanwan Wang; Yang Wang; Xiao Qian; Engin Akkaya

doi:10.1039/d5md00911a

January 1, 2026RSC Medicinal Chemistry

Hypoxia-Triggered Dichloroacetate Delivery with Effective Reversal of Cancer Cell Reprogramming

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Key Points

To investigate how hypoxia-triggered delivery of dichloroacetate can reverse metabolic reprogramming in cancer cells.
Structural modification of dichloroacetate for enhanced delivery
Analysis of cancer cell metabolic pathways under hypoxia
Evaluation of cytotoxic effects in cancer cell lines
DCA effectively inhibited pyruvate dehydrogenase kinase activity
Significant reversal of altered metabolic pathways in cancer cells
Enhanced cytotoxicity noted under hypoxic conditions

Implication

Exploration shows effective reversal of cancer cell reprogramming using hypoxia-triggered dichloroacetate delivery, suggesting therapeutic potential.

Abstract

Dichloroacetate (DCA) is a known inhibitor of pyruvate dehydrogenase kinase, which is part of the key enzyme complex in metabolic reprogramming of cancer cells. In this work, we structurally modified...

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Cite This Study

sun et al. (2026) studied this question.

synapsesocial.com/papers/69a7cc7ad48f933b5eed805b https://doi.org/10.1039/d5md00911a

View Full Paper

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Hypoxia-Triggered Dichloroacetate Delivery with Effective Reversal of Cancer Cell Reprogramming

Key Points

Implication

Abstract

Discussion

Cite This Study

Hypoxia-Triggered Dichloroacetate Delivery with Effective Reversal of Cancer Cell Reprogramming

Key Points

Implication

Abstract

Discussion

Cite This Study

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