Case report demonstrates facial dermatitis from cocamidopropyl betaine in one patient, suggesting cross-reactivity with related compounds.
We present the case of a patient with facial dermatitis caused by sensitization to cocamidopropyl betaine. The patient also had positive patch-test reactions to cocamidoamine, 3-(dimethylamino)propylamine, and oleamidopropyl dimethylamine. The presence of 3-(dimethylamino)propylamine as an impurity in all of these substances can be hypothesized to explain these simultaneous reactions.
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Moreau et al. (2004) studied this question.
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