What question did this study set out to answer?

The study aims to investigate the association between normalization of alkaline phosphatase (ALP) and complication-free survival in primary biliary cholangitis (PBC).

March 4, 2026The American Journal of Gastroenterology0 citations

View Full Paper

Impact of Alkaline Phosphatase Normalization on Complication-Free Survival in Primary Biliary Cholangitis

ARA. Nagarjuna ReddyUniversity of Miami AMAdrielly MartinsUniversity of Miami CBChristopher L. BowlusUniversity of California, Davis

Key Points

The study aims to investigate the association between normalization of alkaline phosphatase (ALP) and complication-free survival in primary biliary cholangitis (PBC).
Analyzed data from patients with primary biliary cholangitis.
Assessed biochemical markers, specifically alkaline phosphatase (ALP) and total bilirubin (TB).
Identified high-risk patients based on baseline characteristics.
Evaluated complication-free survival rates based on ALP normalization.
Patients achieving normal ALP levels showed significantly higher complication-free survival.
High-risk patients benefited the most from ALP normalization.
A biochemical threshold of TB ≤0.6xULN was crucial for enhanced outcomes.

Abstract

Achieving normal ALP and TB ≤0.6xULN is associated with significantly improved complication-free survival, particularly in high-risk patients. These findings highlight the potential of biochemical thresholds as a meaningful therapeutic goal in PBC management.

Ask AI

Helpful

Bookmark

View Full Paper

Ask AI

Helpful

Bookmark

View Full Paper

Impact of Alkaline Phosphatase Normalization on Complication-Free Survival in Primary Biliary Cholangitis

Key Points

Abstract

Cite This Study

Also Consider

Also Consider