Background/aims To evaluate retinal microvascular changes using optical coherence tomography angiography (OCTA) and their prognostic value in patients undergoing transsphenoidal surgery for pituitary adenoma. Methods In this prospective study of 90 patients, we assessed best-corrected visual acuity (BCVA), mean deviation (MD) on visual field (VF), and OCTA parameters at the macular region and peripapillary area. Results Patients with severe VF defects (VFD; MD –3 dB) (p=0.021, 0.047). Higher SCP density, RPC density, peripapillary retinal nerve fibre layer (pRNFL) thickness and ganglion cell complex (GCC) thickness were associated with better postoperative visual acuity (r=−0.33, –0.44, −0.24, –0.30; all p50% MD improvement were 0.816 (SCP density), 0.784 (RPC density), 0.887 (pRNFL thickness), 0.816 (GCC thickness) and 0.905 (combined; all p≤0.001). Conclusions After decompression surgery, retinal vessel densities may further decline at 3 months postoperatively, particularly in patients with severe baseline VFD. Foveal parameters predicted visual acuity in those with mild to moderate VFD, while in severe cases, higher SCP density, RPC density, pRNFL thickness and GCC thickness may serve as prognostic biomarkers for predicting better VF improvement.
Lai et al. (Mon,) studied this question.