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March 4, 2026Open Access

The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders

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Authors

AGAndrew D. GrotzingerJWJosefin WermeAmsterdam NeuroscienceWPWouter Peyrot

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Implication

Analyses uncover genetic overlap in psychiatric disorders, indicating shared biological pathways for comorbid conditions.

Key Points

  • This research aims to explore the shared and disorder-specific genetic influences among various psychiatric disorders.
  • Applied statistical genetic methods to analyze genetic data from 1,056,201 cases
  • Conducted functional genomic analyses to identify underlying biological factors
  • Characterized five genomic factors representing genetic variance across 14 psychiatric disorders
  • Identified five genetic factors explaining approximately 66% of the genetic variance across disorders
  • Uncovered 268 pleiotropic loci associated with multiple disorders
  • Noted significant genetic overlap between schizophrenia, bipolar disorder, and internalizing disorders such as major depression and PTSD

Cite This Study

Grotzinger et al. (2025) studied this question.

synapsesocial.com/papers/69a7ccd5d48f933b5eed8a00https://doi.org/10.3929/ethz-c-000793759
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