Fe 3 O 4 -graphene oxide nanocomposites functionalized with hyaluronic acid and folic acid as dual pH/NIR-responsive platforms for synergistic chemophotothermal therapy of breast cancer

Key Points

• The aim is to develop multifunctional nanocomposites for enhanced therapeutic efficacy in breast cancer treatment.
• Synthesis of Fe3O4-graphene oxide nanocomposites
• Functionalization with hyaluronic acid and folic acid
• Evaluation of drug delivery mechanisms
• Assessing the pH and NIR responsiveness
• The nanocomposites showed effective drug loading and release under specific conditions.
• Synergistic therapy significantly inhibited tumor cell growth.
• Responsive features enhanced therapeutic outcomes in vitro.