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March 4, 2026PLoS ONEOpen Access

Development of immortalized Callithrix jacchus kidney cell lines supporting infection with a panel of viruses

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Authors

SGSabine GärtnerPSPamela StombergSPStefan Pöhlmann

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Overview

Develops kidney cell lines from marmosets to investigate viral infections, suggesting valuable resources for biomedical research.

Key Points

  • The aim is to generate new immortalized kidney cell lines from Callithrix jacchus to enhance infectious disease modeling.
  • Generated three immortalized cell lines from marmoset kidney tissue by transducing with SV40 large T antigen.
  • Characterized the cell lines using RNA sequencing to determine their origin and gene expression profiles.
  • Assessed the responsiveness of cell lines to human and marmoset interferons and tested for viral susceptibility.
  • Cell lines exhibited an epithelioid morphology and were likely derived from pericytes.
  • All cell lines showed a functional interferon system, responding to human IFNβ and marmoset IFNα14.
  • These cell lines demonstrated high permissiveness to Zika virus and Herpes simplex virus 1.

Cite This Study

Gärtner et al. (2026) studied this question.

synapsesocial.com/papers/69a7ccf7d48f933b5eed8e27https://doi.org/10.1371/journal.pone.0337680
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