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Synapse
March 4, 2026Current Opinion in Hematology2 citations

Protease-activated receptors in endothelial health and dysfunction

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KMKaushik MuralidharanLBLivia M. BogdanBKBryce A. Kerlin

Key Points

  • The research aims to explore the role of protease-activated receptors in maintaining endothelial health and understanding dysfunction.
  • Analyzed the function of endothelial protease-activated receptors (PARs) in the vascular environment.
  • Investigated the effects of pathway-specific modulation on vascular health and dysfunction.
  • Reviewed therapeutic approaches targeting endothelial PARs for improved vascular treatments.
  • Identified PARs as critical sensors of the vascular protease environment.
  • Demonstrated that pathway-specific modulation can preserve protective signaling while minimizing vascular damage.
  • Opened avenues for more precise vascular therapeutic strategies.

Abstract

These insights reposition endothelial PARs as sophisticated sensors of the vascular protease environment. Future therapies are moving away from broad receptor blocking toward pathway-specific modulation that maintains protective signaling while reducing vascular damage, opening new avenues for precise vascular treatments.

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Cite This Study

Muralidharan et al. (2026) studied this question.

synapsesocial.com/papers/69a7ccf7d48f933b5eed8e77https://doi.org/10.1097/moh.0000000000000915
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