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March 4, 2026

Hydrogel-Based Airway-on-Tube With Perfusable Endothelial Lumen and Outward Epithelialization.

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Authors

ADAli DoryabJMJoseph M. MurphyMBMichael Bartolf-Kopp

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Overview

Introduces a novel airway-on-tube model that enhances lung research by enabling dynamic endothelial-epithelial interactions.

Key Points

  • The research aims to develop an advanced airway-on-tube model that simulates the complexity of lung tissue for therapeutic testing.
  • Created a hydrogel-based airway-on-tube integrating engineered extracellular matrix
  • Utilized melt electrowriting (MEW) for scaffold reinforcement
  • Cultured primary human lung microvascular endothelial cells within hydrogel to form a perfusable lumen
  • Maintained primary human bronchial epithelial cells on the outer surface for outward epithelialization
  • Applied pulsatile perfusion to deliver nutrients and mechanical cues
  • Established a functional perfusable endothelial lumen in the airway-on-tube model
  • Successfully cultured an outward-facing epithelium at the air-liquid interface (ALI)
  • Demonstrated dynamic endothelial-epithelial interactions under pulsatile perfusion
  • Showed that the model supports preclinical lung research and therapeutic development

Cite This Study

Doryab et al. (2026) studied this question.

synapsesocial.com/papers/69a7ccf7d48f933b5eed8e7fhttps://doi.org/10.1002/adma.202523588
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