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March 4, 2026JAMA Pediatrics5 citations

Plasma Biomarkers of Brain Injury in Critically Ill Children Receiving Extracorporeal Membrane Oxygenation

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MFMatthew L. FriedmanMBM. J. BellBBBonnie A. Brooks

Key Points

  • This research aims to identify plasma biomarkers for real-time monitoring of brain injury in children on ECMO.
  • Evaluated plasma levels of GFAP and NfL in critically ill children on ECMO
  • Analyzed association with patient outcomes
  • Explored potential for guiding neuroprotective strategies
  • GFAP and NfL levels correlate with neurologic status
  • Biomarkers may assist in predicting outcomes
  • Suggests applicability in real-time monitoring during ECMO therapy

Abstract

Results suggest that GFAP and NfL may be promising candidates for real-time neurologic monitoring in children receiving ECMO and may aid in diagnosis, association with outcomes, and potentially guiding neuroprotective strategies.

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Cite This Study

Friedman et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd1dd48f933b5eed9250https://doi.org/10.1001/jamapediatrics.2026.0015
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