What question did this study set out to answer?

The aim is to evaluate how the 2025 NCCN definition affects surgical outcomes after robot-assisted radical prostatectomy for very high-risk prostate cancer.

March 4, 2026Journal of Clinical Oncology

The impact of the 2025 NCCN update in defining very high-risk prostate cancer on surgical outcomes after robot-assisted radical prostatectomy: A retrospective cohort analysis.

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Authors

NMN. MiuraEhime University MSMasaki ShimboSt. Luke's International Hospital KSKensuke SHISHIDOEhime University

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Implication

Retrospective analysis compares surgical outcomes in prostate cancer using updated NCCN definitions, indicating poorer outcomes for some classifications.

Key Points

The aim is to evaluate how the 2025 NCCN definition affects surgical outcomes after robot-assisted radical prostatectomy for very high-risk prostate cancer.
Retrospective review of 1,879 patients who underwent robotic-assisted radical prostatectomy from 2012 to 2022.
Classification of patients into three groups based on NCCN definitions: historical high risk, reclassified high risk, and very high risk under new criteria.
Comparison of biochemical recurrence-free survival and metastasis-free survival among groups.
Group 2 had worse pathological outcomes than Group 1 in terms of stage, Gleason grade, and positive surgical margins.
Five-year biochemical recurrence-free survival rates were 71.1%, 44.7%, and 29.8% for Groups 1, 2, and 3, respectively.
Metastasis-free survival rates were 99.6%, 94.1%, and 88.9% for Groups 1, 2, and 3, respectively.
Exploration of Group 3 revealed poor outcomes for those with high-grade biopsy cores.

Cite This Study

Miura et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd1dd48f933b5eed931a https://doi.org/10.1200/jco.2026.44.7_suppl.340

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Implication

Retrospective analysis compares surgical outcomes in prostate cancer using updated NCCN definitions, indicating poorer outcomes for some classifications.

The impact of the 2025 NCCN update in defining very high-risk prostate cancer on surgical outcomes after robot-assisted radical prostatectomy: A retrospective cohort analysis.

Discussion

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Implication

Key Points

Cite This Study

The impact of the 2025 NCCN update in defining very high-risk prostate cancer on surgical outcomes after robot-assisted radical prostatectomy: A retrospective cohort analysis.

Discussion

Member takes

Implication

Key Points

Cite This Study

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