Population-based analysis reveals distinct patterns in urothelial carcinoma worldwide, highlighting important trends and disparities.
Key Points
To investigate epidemiological patterns of urothelial carcinoma across different regions and demographics.
Utilized cancer registry data from the CI5 Plus database covering 40 countries from 2003 to 2017.
Calculated age-standardized and age-specific incidence rates for bladder, ureteral, and renal pelvic cancers.
Analyzed temporal trends using Joinpoint regression to estimate annual percentage changes.
Examined association between socio-demographic index and UC burden.
In 2017, ASRs for bladder cancer varied significantly by region, with higher rates in developed countries.
ASRs for ureteral and renal pelvic cancers increased globally except in certain developed nations.
Bladder cancer incidence is declining in many developed countries but rising in some developing regions.
A significant correlation exists between UC burden and socio-demographic index, indicating that higher socio-economic development is linked to greater incidence.