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December 11, 2025International Journal of SurgeryOpen Access

Global trends and disparities in uterine corpus cancer by histological subtype: a population-based analysis

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Authors

QZQuan ZhouYGYan GuoSCShuo Chen

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Overview

Population-based analysis reveals significant trends in adenocarcinoma and serous carcinoma across low- and middle-income countries.

Key Points

  • To analyze global trends and disparities in uterine corpus cancer by histological subtype.
  • Population-based study using Cancer Incidence in Five Continents (CI5) data from 1988-2017
  • Age-standardized incidence rates (ASRs) calculated by histological subtype
  • Joinpoint regression used for temporal trends analysis
  • Geospatial mapping conducted to analyze regional patterns
  • Socio-demographic Index (SDI) levels were evaluated for subtype distributions.
  • Distinct geographical patterns noted with Eastern Europe declining in rates while Asia sees increases
  • Adenocarcinoma comprises 84% of cases in high-SDI countries, while unspecified types dominate in low-SDI regions
  • Older adults show high rates of unspecified cases, peaking at ages 65-69
  • Serous carcinoma trends upward by 1.8% per year in North America, contrasting stable endometrioid rates

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/69401b0d2d562116f28f716dhttps://doi.org/10.1097/js9.0000000000004353
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract B021: Early onset uterine corpus cancer incidence rates and 5-year relative survival by histologic subtype and race/ethnicity among women aged 20-49 years2024 · 1 citations
  2. 2From bladder to upper urinary tract: Unveiling the epidemiological dynamics of urothelial carcinoma.2026
  3. 3Forecasting global disparities in cervix and corpus uteri cancers: GLOBOCAN 2022–2040 projections.2026
  4. 4Global burden of uterine cancer: Trends, regional disparities, and projections to 2050—An analysis of GBD 2021 study.2025
  5. 5Incidence Trends and Geographic Variations of Corpus Uteri and Cervical Cancer in Taiwan, 1995–2022: A Population-Based Study2026