Antiplasmodial and cytotoxic activities of secondary metabolites from the leaves of Pleiocarpa bicarpellata Stapf (Apocynaceae)

Q: What does this research mean for the field?

The leaves of Pleiocarpa bicarpellata exhibit significant antiplasmodial activity, with the new compound Bicarpellatoside A showing IC50 values of 2.24 µM against chloroquine-resistant Plasmodium falciparum. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Aurore M. Bella; Guy Roland Ebede; Gaetan B. N. Bayiha; Christelle Tsaffo; Lauve RY Tchokouaha; Rabia Farooq; Fabrice F. Boyom; Huifeng Jiang; Josephine N. Mbing; Joseph Thierry Ndongo; Christian G. Bochet; Hartmut Laatsch

doi:10.1515/znc-2025-0209

February 26, 2026Zeitschrift für Naturforschung C

Antiplasmodial and cytotoxic activities of secondary metabolites from the leaves of Pleiocarpa bicarpellata Stapf (Apocynaceae)

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Key Points

This research aims to investigate the antiplasmodial and cytotoxic activities of isolated compounds from Pleiocarpa bicarpellata leaves.
Isolated secondary metabolites from leaves using phytochemical techniques.
Characterized compounds using NMR, MS, and IR spectroscopy.
Conducted in vitro antiplasmodial tests against Plasmodium falciparum strains (3D7 and Dd2).
The crude extract exhibited strong antiplasmodial activity with IC50 values of 4.07 μg/mL (Dd2) and 4.32 μg/mL (3D7).
Bicarpellatoside A showed significant activity with IC50 values of 2.24 µM (Dd2) and 2.74 µM (3D7).
Compound 4 demonstrated moderate activity with an IC50 of 40.93 µM (Dd2) and a high selectivity index of 34.48.

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Implication

Phytochemical study reveals antiplasmodial efficacy of compounds from Pleiocarpa bicarpellata leaves, suggesting potential for new treatments.

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Cite This Study

Bella et al. (2026) studied this question.

synapsesocial.com/papers/69a7cd2ad48f933b5eed94c4 https://doi.org/10.1515/znc-2025-0209

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Antiplasmodial and cytotoxic activities of secondary metabolites from the leaves of Pleiocarpa bicarpellata Stapf (Apocynaceae)

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Antiplasmodial and cytotoxic activities of secondary metabolites from the leaves of Pleiocarpa bicarpellata Stapf (Apocynaceae)

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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