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The study aims to assess the histological outcomes in women with atypical endometrial cells (AEMc) and the role of HPV status and age in cancer risk.

March 4, 2026Diagnostic PathologyOpen Access

Subclassification of atypical endometrial cells (Not Otherwise Specified vs favor neoplasia) on Pap tests: age-dependent risk of endometrial neoplasia

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Analysis evaluates histological outcomes of atypical endometrial cells in women, highlighting age-related cancer risks.

The study aims to assess the histological outcomes in women with atypical endometrial cells (AEMc) and the role of HPV status and age in cancer risk.
Retrospective analysis of 163 women with atypical endometrial cells diagnosed from January 2019 to December 2023
Conducted liquid-based cytology (LBC) and high-risk HPV testing for 14 genotypes
Performed histological evaluation within six months of cytological assessment
86.5% of AEMc cases were classified as AEMc-not otherwise specified (NOS)
Significantly higher pathological severity in AEMc-favor neoplasia (FN) compared to AEMc-NOS
Older women (aged > 65) had a higher prevalence of high-grade endometrial lesions, indicating greater risk

Zhou et al. (2026) studied this question.

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