A randomized controlled trial compares misoprostol administration methods, revealing serious integrity issues.
M.M. El-Sherbini, A.M. Maged, O.M. Helal, M.O. Awad, S.A. El-Attar, J.A. Sadek, R. ElKomy, M.A. Dawoud "A Comparative Study Between Preoperative Rectal Misoprostol And Intraoperative Intrauterine Administration in The Reduction of Blood Loss During And After Cesarean Delivery: A Randomized Controlled Trial," International Journal of Gynecology & Obstetrics 153, no. 1 (2021): 113-118, https://doi.org/10.1002/ijgo.13426. The above article, published online on 16 October 2020 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Michael Geary; and John Wiley & Sons Ltd. UK. Concerns were raised by a third party regarding recruitment timeline, randomization integrity, and inconsistencies within the presented statistical analysis. Considering these concerns, the authors were asked to provide the raw data. Upon reviewing the study data the authors provided, however, a number of errors in the reported data and results were found. The concerns regarding randomization integrity and recruitment timeline were not alleviated by this review. Further investigation determined that the description of the administration of rectal misoprostol differs from that of the trial registry, which upon review described two different studies. The editorial team and investigators share significant doubt, as does the third party, regarding the conclusions drawn by the authors. In view of this, the article must be retracted.
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