Comparative Evaluation of Manual and Automated Nucleated Red Blood Cell Counts in Neonates: Insights from a Rural North Indian Tertiary Care Centre

March 2, 2026Open Access

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Key Points

The study aims to compare the accuracy of nucleated red blood cell counts using automated versus manual methods in neonates.
Conducted a prospective cross-sectional study with 100 neonates aged 0-28 days.
Compared nRBC counts using a Sysmex XN-1000 automated haematology analyser and manual analysis of leishman-stained smears.
Reported nRBCs per 100 white blood cells (WBCs).
66% of the neonates were male and 83% were aged 0-2 days.
Common symptoms included fever in 56% and jaundice in 22% of neonates.
90% of cases had normal haemoglobin levels (14-24 gm%).
40% of cases showed low nRBC counts based on automated methods.

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This prospective study compares automated and manual nRBC counting in neonates, indicating the method's implications for clinical practice.

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Singhal et al. (2026) studied this question.

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