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The aim is to develop a precision nanoplatform using macrophages to enhance treatment for ovarian cancer peritoneal metastasis.

A Macrophage-Driven Multimodal Nanoplatform Conquers Ovarian Cancer Peritoneal Metastasis

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The aim is to develop a precision nanoplatform using macrophages to enhance treatment for ovarian cancer peritoneal metastasis.
Engineered M1-polarized macrophages for targeted delivery of mitoxantrone-loaded nanoparticles.
Used near-infrared (NIR) irradiation for on-demand drug release.
Implemented a trimodal therapy strategy involving chemotherapy, photothermal ablation, and chemodynamic therapy.
Achieved selective accumulation of nanoparticles at peritoneal metastases.
Induced strong immunogenic cell death, enhancing immune response.
Combined therapy resulted in near-complete eradication of peritoneal metastases in mouse models.

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Researchers demonstrate a new nanoplatform that improves ovarian cancer treatment by activating immune responses and targeting tumors.

Ji et al. (2026) studied this question.

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