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March 4, 2026BiomoleculesOpen Access

Skin-Based α-Synuclein Deposits Detection Across the Prodromal Continuum of Synucleinopathies: Updated Evidence and Perspectives

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Authors

SFSeyed-Mohammad Fereshtehnejad

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Overview

Review summarizes skin-derived biomarkers for early diagnosis of synucleinopathies, suggesting prognostic potential.

Key Points

  • This review aims to explore the role of skin-based biomarkers in detecting α-synuclein during the prodromal phase of synucleinopathies.
  • Review of literature on skin-derived biomarkers and their role in Parkinson's disease.
  • Analysis of skin biopsy-based detection methods for phosphorylated α-synuclein.
  • Examination of seed amplification assays for α-synuclein in high-risk prodromal phenotypes.
  • Skin-derived biomarkers may indicate early pathogenic processes in prodromal Parkinson's disease.
  • Identified α-synuclein pathology in skin may precede motor symptoms and nigrostriatal degeneration.
  • Highlighting the need for more data regarding other prodromal phenotypes such as hyposmia.

Cite This Study

Seyed-Mohammad Fereshtehnejad (2026) studied this question.

synapsesocial.com/papers/69a7cd8cd48f933b5eeda04ehttps://doi.org/10.3390/biom16030376
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