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Synapse
April 5, 2026Open Access

Skin-Based α-Synuclein Deposits Detection Across the Prodromal Continuum of Synucleinopathies : Updated Evidence and Perspectives

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Authors

SFSeyed-Mohammad Fereshtehnejad

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Overview

This review highlights skin-based biomarkers for early diagnosis of synucleinopathies, suggesting their potential impact in clinical settings.

Key Points

  • The aim is to explore biomarkers found in the skin that indicate early stages of synucleinopathies, like Parkinson's disease.
  • Review of current skin-derived biomarkers related to alpha-synuclein.
  • Emphasis on skin biopsy techniques for detecting phosphorylated alpha-synuclein.
  • Assessment of seed amplification assays in the context of synucleinopathies.
  • Skin-derived biomarkers can be detected before the onset of motor symptoms.
  • Alpha-synuclein pathology in skin may signal future neurological issues.
  • Knowledge gaps exist regarding other prodromal phenotypes, such as hyposmia.

Cite This Study

Seyed-Mohammad Fereshtehnejad (2026) studied this question.

synapsesocial.com/papers/69d1fdf7a79560c99a0a4660https://doi.org/10.14288/1.0451746
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