December 1, 2015JACC. Cardiovascular imagingOpen Access

Contrast-Enhanced CMR Overestimates Early Myocardial Infarct Size

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Why the study?

Does contrast-enhanced CMR accurately estimate myocardial infarct size acutely compared to TTC staining?

Population

Acute myocardial infarction model (implied preclinical due to TTC comparison)

Comparison

Contrast-enhanced Cardiac Magnetic Resonance… vs Triphenyltetrazolium chloride staining and CMR…

Design

Preclinical

Follow-up

7 days

Authors

RJRobert JablonowskiCardiac Imaging HEHenrik EngblomCardiac Imaging MKMikael KanskiLund University

Discussion

Member takes

Implication

Acute CMR may overestimate infarct size in animals; hypothesis-generating for optimal timing in clinical MI assessment.

Structured PICO

Does contrast-enhanced CMR accurately estimate myocardial infarct size acutely compared to TTC staining?

Population

Acute myocardial infarction model (implied preclinical due to TTC comparison)

Intervention

Contrast-enhanced Cardiac Magnetic Resonance (CMR) acutely (day 1)

Comparator

Triphenyltetrazolium chloride (TTC) staining and CMR at 7 days

Outcome

Infarct size (IS)surrogate

Contrast-enhanced CMR overestimates infarct size acutely (day 1) compared to histology, suggesting imaging should be delayed to 7 days for accurate assessment.

Cite This Study

Jablonowski et al. (2015) studied this question.

synapsesocial.com/papers/69a8adc13d930da281147c75 https://doi.org/10.1016/j.jcmg.2015.08.015

Topics

Cardiac MRI

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Contrast-Enhanced CMR Overestimates Early Myocardial Infarct Size

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Contrast-Enhanced CMR Overestimates Early Myocardial Infarct Size

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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