Why the study?
Does ACUT2E TSE-SSFP improve SNR and CNR compared to T2-prepared SSFP and TSE in imaging acute myocardial infarction?
Does ACUT2E TSE-SSFP improve SNR and CNR compared to T2-prepared SSFP and TSE in imaging acute myocardial infarction?
ACUT2E TSE-SSFP provides bright-blood T2-weighted imaging with SNR and CNR comparable to dark-blood TSE, while eliminating imperfect blood suppression artifacts.
TSE-SSFP enables bright-blood T2-weighted cardiac imaging with comparable metrics; leaves open clinical adoption pending patient validation.
ACUT(2)E TSE-SSFP is a hybrid between steady state free precession (SSFP) and turbo spin echo (TSE) for bright-blood T2-weighted imaging with signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) similar to dark-blood TSE. TSE-SSFP uses a segmented SSFP readout during diastole with 180 degrees pulses following a 90 degrees preparation. The 180 degrees refocusing pulses make TSE-SSFP similar to TSE but TSE-SSFP uses gradient moment nulling, whereas TSE uses gradient crushing. TSE-SSFP produced T2-weighted images with minimal T1 weighting. TSE-SSFP and TSE had similar SNR (155.9 +/- 6.0 vs 160.9 +/- 7.0; P = NS) for acute myocardial infarction (MI) and twice the SNR of T2-prepared SSFP (73.1 +/- 3.4, P < 0.001). TSE-SSFP and TSE had approximately double the CNR of T2-prepared SSFP for differentiating acute MI from normal myocardium. Imperfect blood suppression, present in all animals on some TSE images, was a problem eliminated by TSE-SSFP and T2-prepared SSFP.
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Aletras et al. (2008) studied Acute myocardial infarction. ACUT2E TSE-SSFP vs. TSE and T2-prepared SSFP was evaluated on Signal-to-noise ratio (SNR) for acute myocardial infarction (p=NS).
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