High COMP expression promotes tumor cell proliferation and migration of rectal cancer, contributing to unfavorable prognosis and suppressive immune microenvironment

Jin Shang; Wan-Jun Sheng; Jia Hao; Dong V Wang; De-Zhi Yang

doi:10.1007/s12672-026-04675-0

March 2, 2026Discover OncologyOpen Access

High COMP expression promotes tumor cell proliferation and migration of rectal cancer, contributing to unfavorable prognosis and suppressive immune microenvironment

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Key Points

To investigate how COMP expression influences tumor cell behavior in rectal cancer and its implications for prognosis.
Analysis of COMP expression in public rectal cancer cohorts and cell lines.
Use of si-COMP to inhibit COMP expression in cancer cells.
Assessment of effects on cell viability, migration, and invasion.
Higher COMP expression was associated with tumor proliferation and migration.
Inhibiting COMP significantly reduced cell viability and invasive properties.
Findings suggest a pathogenic role for COMP in rectal cancer progression.

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Implication

High COMP expression predicts poor outcomes in rectal cancer, indicating its role in tumor dynamics and immune suppression.

Abstract

Collectively, significant higher COMP expression was noticed in public RC cohorts and RC cells, and si-COMP obviously inhibited the cell viability, migration, and invasion, implying its pathogenic role in RC.

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Cite This Study

Shang et al. (2026) studied this question.

synapsesocial.com/papers/69a91cbed6127c7a504bfaa7 https://doi.org/10.1007/s12672-026-04675-0

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High COMP expression promotes tumor cell proliferation and migration of rectal cancer, contributing to unfavorable prognosis and suppressive immune microenvironment

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

High COMP expression promotes tumor cell proliferation and migration of rectal cancer, contributing to unfavorable prognosis and suppressive immune microenvironment

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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