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This investigation aims to explore the correlation of COMP with disease progression and immunomodulatory factors in colorectal cancer.

Cartilage Oligomeric Matrix Protein (COMP) Correlates with Disease Progression, Selected Immune Checkpoint Molecules and SIGLEC9 in Colorectal Cancer

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Randomized trial finds COMP levels predict disease progression in colorectal cancer, suggesting its role as a therapeutic target.

This investigation aims to explore the correlation of COMP with disease progression and immunomodulatory factors in colorectal cancer.
Quantified COMP in 107 paired colorectal cancer and normal tissues using ELISA.
Conducted Gene Set Enrichment Analysis with FieldEffectCrc dataset and survival analysis in TCGA CRC cohort.
Correlated COMP expression with clinicopathological features, mutational profiles, MSI, and immune checkpoints.
COMP was significantly upregulated in CRC tissues (p < 0.001) and correlated with advanced pathological stages (all p < 0.05).
High COMP linked to reduced immune infiltration (p < 0.05) and higher levels in microsatellite stable tumors than MSI tumors (p < 0.01).
Transcriptomic data associated high COMP with worse disease-specific survival and enrichment in pro-tumorigenic pathways.

Limanówka et al. (2026) studied this question.

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