This research demonstrates enhanced spirocyclobutane formation via cation rearrangement, suggesting broader synthetic applications.
Accessing spirocyclobutanes via cyclopropylcarbinyl cation rearrangements remains challenging due to competing pathways. Herein, we report an HFIP-enabled, BF₃-catalyzed rearrangement-cyclization of cyclopropylcarbinyl alcohols, delivering diverse spirocyclobutanes in up to 95% yield. Subsequent derivatizations highlight synthetic utility, while DFT studies reveal that HFIP reshapes the reaction energy landscape to enhance the reactivity and selectivity.
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Geng et al. (2026) studied this question.
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