Case report highlights high mortality and diagnostic challenges of Scedosporium apiospermum endocarditis in immunocompetent individuals, suggesting urgent intervention needs.
S. apiospermum endocarditis carries a grave prognosis. Among 18 reviewed articals, 19 patients succumbed to the infection, 7 of whom were diagnosed postmortem, precluding therapeutic intervention. Only one survivor was reported following implantable cardioverter-defibrillator (ICD) extraction and voriconazole treatment. These findings underscore the insidious onset, diagnostic challenges, frequent therapeutic delays, and extremely high mortality associated with this infection.
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Zhang et al. (2026) studied this question.
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