Muribaculum intestinale alleviates depressive-like behaviors by inhibiting Th17 cell differentiation and M1 microglia polarization

Key Points

• To explore how Muribaculum intestinale affects depressive-like behaviors and related immune mechanisms.
• Investigated the role of Muribaculum and SCFAs in depression models.
• Examined Th17 cell differentiation and M1 microglia polarization.
• Evaluated antidepressant-like effects of loganin in preclinical settings.
• Loganin enriched Muribaculum and increased SCFA levels.
• Inhibition of Th17 cell differentiation was observed with Muribaculum.
• Reduced M1 microglia polarization linked to improved depressive-like behaviors.