In healthy adults, a modified RNA vs. inactivated influenza vaccine reduced laboratory-confirmed influenza-like illness at ≥14 d

Rahul Anand; Aaron E. Glatt

doi:10.7326/annals-25-05681-jc

March 2, 2026Annals of Internal Medicine

In healthy adults, a modified RNA vs. inactivated influenza vaccine reduced laboratory-confirmed influenza-like illness at ≥14 d

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Key Points

The aim is to compare the effectiveness of a modified RNA vaccine versus an inactivated influenza vaccine in reducing influenza-like illness.
Comparison of modified RNA and inactivated influenza vaccines
Involvement of healthy adult participants
Observation of laboratory-confirmed influenza-like illnesses
Follow-up period of ≥14 days post-vaccination
The modified RNA vaccine significantly reduced occurrences of influenza-like illness compared to the inactivated vaccine
Laboratory-confirmed cases were lower among those receiving the modified RNA vaccine
Improvements were observed at least 14 days post-vaccination

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Implication

Compares modified RNA and inactivated influenza vaccines, revealing their effectiveness in preventing illness in healthy adults, suggesting a promising vaccine strategy.

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Anand et al. (2026) studied this question.

synapsesocial.com/papers/69a91cf1d6127c7a504bfd43 https://doi.org/10.7326/annals-25-05681-jc

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In healthy adults, a modified RNA vs. inactivated influenza vaccine reduced laboratory-confirmed influenza-like illness at ≥14 d

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

In healthy adults, a modified RNA vs. inactivated influenza vaccine reduced laboratory-confirmed influenza-like illness at ≥14 d

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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