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March 5, 2026Surgical Case Reports0 citationsOpen Access

Radiation-Induced Angiosarcoma Following Breast Surgery: A Case Report

MHMutsumi HayashiJuntendo University Nerima HospitalYKYukino KobayashiJuntendo University Nerima HospitalRSRyoko SembaJuntendo University

Key Result

Total mastectomy with wide skin excision completely relieved breast pain and resulted in recurrence-free status at 6 months in a 72-year-old woman with radiation-induced breast angiosarcoma.

Key Points

  • This case report aims to describe the occurrence of radiation-induced angiosarcoma following breast surgery.
  • Presented a detailed case of a patient with radiation-induced angiosarcoma
  • Discussed the timeline from surgery to diagnosis
  • Emphasized the importance of surgical excision for treatment
  • Confirmed angiosarcoma developed years after radiation therapy
  • Noted poor prognosis associated with this condition
  • Highlighted successful management through early diagnosis and complete excision

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

P
Population
1 72-year-old woman with radiation-induced angiosarcoma of the left breast presenting with multiple painful, dark purple nodules 7 years after breast-conserving surgery and adjuvant radiation therapy for adenoid cystic carcinoma.
I
Intervention
Total mastectomy with wide skin excision, including all overlying breast skin, and split-thickness skin grafting from the left thigh.

This case report highlights that early recognition and complete surgical excision with wide margins are essential for managing radiation-induced angiosarcoma of the breast.

Limitations

  • Single patient case report without comparator group
  • Short follow-up duration of 6 months
  • Lack of systemic therapy limits generalizability to other treatment contexts

Abstract

INTRODUCTION: Radiation-induced angiosarcoma of the breast is a rare but aggressive secondary malignancy that develops several years after breast surgery and adjuvant radiation therapy. Because of its poor prognosis and diagnostic challenges, early recognition and complete surgical excision are essential for optimal management.

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Cite This Study

Hayashi et al. (2026) conducted a case report in 72-year-old woman with radiation-induced angiosarcoma of the breast developing 7 years after breast-conserving surgery and adjuvant radiation therapy for adenoid cystic carcinoma (n=1). Total mastectomy with wide skin excision and split-thickness skin grafting was evaluated on Recurrence-free survival at 6 months after complete surgical resection. Total mastectomy with wide skin excision completely relieved breast pain and resulted in recurrence-free status at 6 months in a 72-year-old woman with radiation-induced breast angiosarcoma.

synapsesocial.com/papers/69a91d21d6127c7a504bfe3chttps://doi.org/10.70352/scrj.cr.25-0674
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