Radiation-Induced Angiosarcoma Following Breast Surgery: A Case Report

Figures

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  Fig. 1. Clinical photograph at initial examination. (A) A dark red nodule with surrounding erythema is visible in the left breast (blue arrows and blue dotted line). (B) The previous surgical scar from breast-conserving surgery is also identifiable (red arrow).

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  Fig. 2. Ultrasonographic findings. Multiple irregular hypoechoic masses, some with suspected skin invasion (red arrow).

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  Fig. 3. MRI findings. (A) Lateral 3D reconstruction showing multiple vascularized masses (red arrows). (B–D) Axial views demonstrating heterogeneous contrast enhancement.

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  Fig. 4. Intraoperative image. Wide skin excision of the left breast including the overlying skin, followed by split-thickness skin grafting harvested from the left thigh.

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  Fig. 5. Macroscopic findings. (A) The entire left breast and overlying skin were excised en bloc. A nodule is exposed on the lateral side of the nipple. (B) Mapping image. Two incisions were made directly above the tumor before formalin fixation. The tumor extensively infiltrates the surrounding tissue.

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  Fig. 6. Histopathologic findings. (A) Hematoxylin and eosin staining showing numerous poorly differentiated spindle-shaped tumor cells with endothelial proliferation into the vascular lumen. (B) CD31 immunohistochemistry showing strong membranous positivity in vascular endothelial cells, supporting endothelial differentiation.