Why the study?
Radiation-induced breast sarcoma is an iatrogenic malignancy with a poor prognosis, underscoring the need to consider it in the differential diagnosis of recurrent breast neoplasms.
Highlights the importance of considering radiation-induced angiosarcoma as a differential diagnosis in patients with recurrent breast neoplasms after radiotherapy.
Bilateral radiation-induced breast angiosarcoma may arise by 5 years; leaves open optimal surveillance protocols in survivors.
Radiation-induced sarcoma of the breast is an iatrogenic malignancy that occurs secondary to radiotherapy, which is most commonly given following breast conservation surgery. It has an incidence of 3.2 per 1,000 patients at 15 years and is associated with a poor prognosis. We report a 62-year-old female with a history of bilateral breast conservation surgery and radiotherapy 5 years ago presenting with bilateral angiosarcoma. This case report highlights the importance of considering radiation-induced angiosarcoma of the breast as a differential diagnosis in a patient with recurrent breast neoplasms. The challenges in the management with recent evidence on new treatment modalities are discussed.
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Jayarajah et al. (2020) studied this question.
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