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March 5, 2026SHILAP Revista de lepidopterologíaOpen Access

Erythropoietin alleviate obstructive renal fibrosis by regulating immunity and inflammation through miR-21-5p/SPRY1/ERK1/2/NF-κB pathway inhibition

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Authors

ELErpeng LiuXSXiao SunQLQ Y Liu

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Overview

Demonstrates how erythropoietin reduces renal fibrosis by regulating inflammation and immune response in mice, suggesting therapeutic potential.

Key Points

  • The aim is to explore how erythropoietin affects renal fibrosis through immune and inflammatory regulation, focusing on specific molecular pathways.
  • Utilized a mouse model of unilateral ureteral obstruction (UUO) with ligated ureters.
  • Administered low-dose recombinant erythropoietin (rhEPO) at 100 U/kg for 7 days.
  • Conducted in vitro experiments using HK-2 cells to validate signaling pathways.
  • Low-dose rhEPO significantly alleviated fibrosis and inflammation in obstructive kidneys.
  • RhEPO treatment reversed the upregulation of miR-21-5p and activation of the SPRY1/ERK/NF-κB pathway.
  • This study provides novel evidence of EPO's anti-fibrotic effects through modulation of immune and inflammatory responses.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69a91d21d6127c7a504bfee0https://doi.org/10.3389/fmolb.2026.1795772
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