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March 5, 2026PLoS ONEOpen Access

COVID-19 knowledge, attitudes, and practices among people vulnerable to HIV in Uganda: A cross-sectional cohort analysis

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Authors

JKJob KasuleSDShari DavisNBNatalie Burns

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Overview

Cross-sectional cohort analysis reveals gaps in COVID-19 preventive practices among those vulnerable to HIV, suggesting intervention needs.

Key Points

  • This research aims to understand COVID-19 knowledge, attitudes, and practices among individuals vulnerable to HIV in Uganda.
  • Conducted a cross-sectional cohort study from October 2022 to September 2024.
  • Enrolled participants aged 14–55 years without HIV, with recent behavioral vulnerabilities.
  • Collected socio-behavioral data, including assessments of COVID-19 knowledge, attitudes, and practices.
  • Employed robust Poisson regression to estimate prevalence ratios for COVID-19 preventive practices.
  • Among 418 participants, 56.9% were female with a median age of 21 years.
  • High knowledge about SARS-CoV-2 transmission routes (95.4%) but variable knowledge on genetic variants (48.5%−69.7%).
  • Practices included handwashing (90.8%), but lower rates for mask-wearing (76.5%) and vaccination (46.9%).
  • Males were more likely to avoid symptomatic individuals and report vaccination, while Omicron wave enrollment linked to higher vaccination but lower mask-wearing.

Cite This Study

Kasule et al. (2026) studied this question.

synapsesocial.com/papers/69a91d55d6127c7a504c01c2https://doi.org/10.1371/journal.pone.0343507
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