Diastolic blood pressure, but not systolic blood pressure, was significantly associated with log plasma aldosterone concentration, log plasma renin activity, and log aldosterone-to-renin ratio in patients with essential hypertension (p<0.001).
Observational (n=548)
Elevated aldosterone levels are relatively common in Chinese patients with essential hypertension and are an independent risk factor for increased diastolic blood pressure.
Effect estimate: Regression analysis F and p values
p-value: p=For diastolic BP vs log PAC: F=23.491, p=0.000; diastolic BP vs log PRA: F=20.508, p=0.000; diastolic BP vs log ARR: F=13.816, p=0.000; systolic BP analyses all not significant
Background A study indicates that elevated aldosterone levels increase the risk of hypertension by 16%. This retrospective cohort study examines the relationship between blood pressure and renin-aldosterone levels in patients with essential hypertension (EH), aiming to elucidate the clinical features and risk factors of inappropriate hyperaldosteronism in Chinese individuals with essential hypertension. Methods Clinical data of 309 EH patients were analyzed. The participants were divided into three groups with a high (H)/medium (M)/low (L) blood pressure level: Group H (BP≥160 / (or) 100 mmHg, n = 151), Group M (BP 140–160/90–100 mmHg, n = 101), Group L (BP 0.05). The proportion of patients with heightened aldosterone levels was greater in Group H compared to the others (23.8% vs. 20.8% and 14.0%, p < 0.05). Multiple linear stepwise regression indicated that higher aldosterone levels correlated with increased diastolic blood pressure. PAC increased by 3.66 ng/dL for every 10 mmHg of DBP. Conclusion The increase in aldosterone levels is relatively common among EH patients in China. The increase in aldosterone levels is correlated with the elevation of diastolic blood pressure. The elevated aldosterone levels are an independent risk factor for the increase in diastolic blood pressure in EH patients.
Li et al. (Tue,) conducted a observational in Patients with essential hypertension (n=548). Diastolic blood pressure, but not systolic blood pressure, was significantly associated with log plasma aldosterone concentration, log plasma renin activity, and log aldosterone-to-renin ratio in patients with essential hypertension (p<0.001).