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March 5, 2026Blood5 citations

Anti-CD7 fratricide-resistant chimeric antigen receptor T cells for relapsed/refractory acute myeloid leukemia

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MBMarco BecilliPMPietro MerliMAMattia Algeri

Key Points

  • To evaluate the effectiveness of anti-CD7 CAR T-cells in preventing fratricide and achieving disease remission in patients with acute myeloid leukemia.
  • Infused second-generation CD7-directed CAR T-cells in pediatric/young adult patients
  • Used an anti-CD7 protein expression blocker to prevent self-killing
  • Monitored for measurable residual disease status
  • Achieved measurable residual disease negativity in all treated patients
  • Demonstrated a favorable safety profile
  • Addressed issues of fratricide associated with traditional CAR T-cell therapies

Abstract

Autologous second-generation CD7-directed CAR T-cells, expressing an anti-CD7 protein expression blocker to prevent self-killing fratricide, were infused in three pediatric/young adult patients with relapsed/refractory CD7+ acute myeloid leukemia resulting in measurable residual disease negativity. The safety profile was favorable.

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Cite This Study

Becilli et al. (2026) studied this question.

synapsesocial.com/papers/69a91d9bd6127c7a504c08adhttps://doi.org/10.1182/blood.2025032299
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CD7 CAR-T therapy: current developments, improvements, and dilemmas2025 · 3 citations
  2. 2Case report: Preventive infusion of donor-derived CD7 chimeric antigen receptor T cells after allogeneic hematopoietic stem cell transplantation2024 · 4 citations
  3. 3CD7 chimeric antigen receptor T cells for relapsed/refractory T-cell lymphomas: Single-arm, open-label, phase I study2025
  4. 4<scp>InsT‐ALLing CD7</scp> chimeric antigen receptors before transplantation2024 · 1 citations
  5. 5IL7-Receptor–Targeted CAR T-Cell Therapy for T-Cell Acute Lymphoblastic Leukemia2026