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March 5, 2026EMBO ReportsOpen Access

NimA promotes cell adhesion at the blood brain barrier of the Drosophila nervous system

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Authors

RSRosy SakrSMSara MonticelliSSSmrithi Kizhakkenottiyath Shasthadevan

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Overview

Investigation reveals NimA supports cell adhesion in glial cells, indicating its role in neural development.

Key Points

  • The study aims to uncover the specific roles of glial cells in the blood-brain barrier of Drosophila, focusing on the protein NimA.
  • Comparison of transcriptomes among glial cells, neurons, and macrophages.
  • Identification of glial-specific proteins, particularly NimA.
  • Assessment of barrier integrity and neural development after manipulating NimA expression.
  • NimA is identified as a glial-specific protein involved in cell adhesion.
  • Loss of NimA compromises the integrity of the blood-brain barrier.
  • Absence of NimA delays development, reduces brain size, and impairs neural stem cell proliferation.

Cite This Study

Sakr et al. (2026) studied this question.

synapsesocial.com/papers/69a91d9bd6127c7a504c0938https://doi.org/10.1038/s44319-026-00728-1
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