What question did this study set out to answer?

To synthesize current knowledge on how the placenta handles glucose in uncomplicated human pregnancies, focusing on active regulation mechanisms.

March 5, 2026PlacentaOpen Access

Placental handling of glucose in the human – beyond the maternal-fetal glucose gradient

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This review synthesizes mechanisms of placental glucose handling, emphasizing implications for fetal growth in uncomplicated pregnancies.

To synthesize current knowledge on how the placenta handles glucose in uncomplicated human pregnancies, focusing on active regulation mechanisms.
Review of existing literature on placental glucose metabolism and its role in fetal energy supply.
Examination of dynamic processes including glucose consumption, storage, and synthesis within the placenta.
Analysis of in vivo studies measuring glucose release from placental sources to the fetus.
Up to 70% of glucose supplied to the fetus can originate from placental sources at specific times.
Placental glucose handling switches between consumption and release according to fetal needs.
Aerobic glycolysis and significant lactate export to maternal circulation are core features of placental metabolism.

Henriksen et al. (2026) studied this question.

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