What question did this study set out to answer?

The aim is to assess the effects of estetrol on mitochondrial function and neuronal morphology in Alzheimer’s disease models.

March 5, 2026CellsOpen Access

Estetrol Enhances Mitochondrial Bioenergetics and Neurite Outgrowth in Cellular Models of Alzheimer’s Disease

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Authors

AGAmandine GrimmUniversity of Basel ARAurélien RiouUniversitäre Psychiatrische Kliniken Basel CGClara GaillardUniversitäre Psychiatrische Kliniken Basel

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Implication

Evaluates estetrol's effects on mitochondrial bioenergetics and neurite development in Alzheimer's disease models, suggesting a potential therapeutic option.

Key Points

The aim is to assess the effects of estetrol on mitochondrial function and neuronal morphology in Alzheimer’s disease models.
Evaluated human SH-SY5Y neuroblastoma cells in models of Alzheimer’s disease (AD) with amyloid precursor and tau overexpression.
Measured ATP levels, mitochondrial membrane potential, and oxidative respiration.
Assessed neurite outgrowth in response to E4 treatment.
Analyzed gene expression of key mitochondrial components.
E4 significantly increased ATP levels and mitochondrial respiration in all tested models.
E4 exceeded E2's effects in P301L tau overexpressing cells.
Promoted significant neurite outgrowth compared to AD models without E4 treatment.
E4 modulated expression of SLC25A23 (upregulated) and NDUFA1 (downregulated) genes.

Cite This Study

Grimm et al. (2026) studied this question.

synapsesocial.com/papers/69a91dd2d6127c7a504c1027 https://doi.org/10.3390/cells15050452

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Implication

Evaluates estetrol's effects on mitochondrial bioenergetics and neurite development in Alzheimer's disease models, suggesting a potential therapeutic option.

Estetrol Enhances Mitochondrial Bioenergetics and Neurite Outgrowth in Cellular Models of Alzheimer’s Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

Estetrol Enhances Mitochondrial Bioenergetics and Neurite Outgrowth in Cellular Models of Alzheimer’s Disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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