Whole-genome sequencing reveals similar cancer mutations in cats and humans, suggesting cats for oncology studies.
Whole-genome sequencing of nearly 500 paired tumor–normal cat tissue samples, representing 13 cancers, has uncovered strong similarities with the human oncogenome, including recurrently mutated TP53 as a driver of multiple tumor types. This is the first time the domestic feline oncogenome has been comprehensively characterized, and the human parallels support utilizing cats more frequently in comparative oncology.
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