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The study investigates cognitive deficits in schizophrenia with respect to TLR activity and antipsychotic doses, suggesting complex interactions.
Our data indicate that the dose of antipsychotic drugs alone cannot predict changes in cognitive performance and TLR4-activity. It also suggests that antipsychotic drug doses significantly affect TLR activity and its relationship with cognition. These effects are more pronounced on some domains than others. These findings open up new avenues for understanding the complex interplay between antipsychotic drugs, TLRs, and cognitive deficits in SZ.
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Patlola et al. (2026) studied this question.
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