A difluorocarbene-triggered annulation/ring expansion cascade via sequential single-atom-insertions: direct assembly of 2-fluoroquinazolinones from azo compounds

Y. W. Tian; Yiyan Xiong; Jingyu Wei; Gongming Zhu; Junbiao Chang; Bingxian Liu

doi:10.1039/d6sc00897f

January 1, 2026Chemical ScienceOpen Access

A difluorocarbene-triggered annulation/ring expansion cascade via sequential single-atom-insertions: direct assembly of 2-fluoroquinazolinones from azo compounds

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Key Points

This research aims to develop an efficient method for synthesizing 2-fluoroquinazolinones using difluorocarbene.
Utilized difluorocarbene as a key reagent
Implemented a tandem reaction strategy
Focused on sequential single-atom-insertion steps
Successfully synthesized 2-fluoroquinazolin-4(3H)-ones
Demonstrated the efficiency of the tandem strategy
Showed potential for broader applications in organic synthesis

Implication

A tandem strategy synthesizes 2-fluoroquinazolinones from azo compounds, revealing a novel insertion process.

Abstract

An efficient difluorocarbene-mediated tandem strategy for the synthesis of 2-fluoroquinazolin-4(3 H )-ones via a sequential single-atom-insertion process has been developed.

Discussion

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Cite This Study

Tian et al. (2026) studied this question.

synapsesocial.com/papers/69a91e12d6127c7a504c1aab https://doi.org/10.1039/d6sc00897f

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A difluorocarbene-triggered annulation/ring expansion cascade via sequential single-atom-insertions: direct assembly of 2-fluoroquinazolinones from azo compounds

Key Points

Implication

Abstract

Discussion

Cite This Study

A difluorocarbene-triggered annulation/ring expansion cascade via sequential single-atom-insertions: direct assembly of 2-fluoroquinazolinones from azo compounds

Key Points

Implication

Abstract

Discussion

Cite This Study

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