Single Nucleotide Polymorphism Microarray Analysis Unveils Copy-Number Abnormalities and Genetic Heterogeneity in Malaysian Childhood B-Cell Precursor Acute Lymphoblastic Leukemia.

Nor Soleha Mohd Dali; Nursaedah Abdullah Aziz; Muhamad Farid Zulkifle; Durar Aqilah Zamri; Nor Rizan Kamaluddin; Seoh-Leng Yeoh; Betty Lee-Sue Ho; Nazzlin Dizana Din; Azly Sumanty Ab Ghani; Wan Amal Hayati Wan Hassan; Zubaidah Zakaria; Ezalia Esa; Yuslina Mat Yusoff

doi:10.1002/mgg3.70182

March 1, 2026

Single Nucleotide Polymorphism Microarray Analysis Unveils Copy-Number Abnormalities and Genetic Heterogeneity in Malaysian Childhood B-Cell Precursor Acute Lymphoblastic Leukemia.

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Key Points

The aim is to analyze genetic variations in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) using advanced techniques.
Utilized SNP 6.0 microarray technology
Employed multiplex ligation-dependent probe amplification (MLPA)
Analyzed genetic data from Malaysian childhood BCP-ALL cases
Identified significant copy-number abnormalities in BCP-ALL cases
Revealed a complex genetic landscape within the Malaysian population
Facilitated insights for more personalized treatment approaches

Implication

Combined SNP microarray and MLPA reveals genetic variations in childhood BCP-ALL, suggesting improved treatment strategies.

Abstract

This study demonstrates the utility of combined SNP 6.0 microarray and MLPA in providing a comprehensive and refined understanding of the genetic landscape of BCP-ALL in the Malaysian population. This understanding may facilitate risk stratification and the development of personalized treatment strategies.

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Cite This Study

Dali et al. (2026) studied this question.

synapsesocial.com/papers/69a91e1fd6127c7a504c1bb0 https://doi.org/10.1002/mgg3.70182

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Single Nucleotide Polymorphism Microarray Analysis Unveils Copy-Number Abnormalities and Genetic Heterogeneity in Malaysian Childhood B-Cell Precursor Acute Lymphoblastic Leukemia.

Key Points

Implication

Abstract

Discussion

Cite This Study

Single Nucleotide Polymorphism Microarray Analysis Unveils Copy-Number Abnormalities and Genetic Heterogeneity in Malaysian Childhood B-Cell Precursor Acute Lymphoblastic Leukemia.

Key Points

Implication

Abstract

Discussion

Cite This Study

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